LOS ANGELES, United States, June 17, 2025 (BSS/AFP) - The main doctor charged in connection with the drug overdose of American-Canadian actor and "Friends" star Matthew Perry is expected to enter a guilty plea in the coming weeks, the US Justice Department said Monday.

Salvador Plasencia "has agreed to plead guilty to four counts of distribution of ketamine, which carries a statutory maximum sentence of 40 years in federal prison," the department said in a statement.

The second doctor in the case, Mark Chavez, pleaded guilty last October to conspiring to distribute ketamine in the weeks before the actor was found dead in the hot tub of his Los Angeles home in 2023.

Perry's lengthy struggles with substance addiction were well-documented, but his death at age 54 sent shockwaves through the global legions of "Friends" fans.

A criminal investigation was launched soon after an autopsy discovered the actor had high levels of ketamine -- an anesthetic -- in his system.

Plasencia allegedly bought ketamine off Chavez and sold it to the desperate star at hugely inflated prices.

Jasveen Sangha, the alleged "Ketamine Queen" who supplied drugs to high-end clients and celebrities, is charged with selling Perry the dose that killed him.

She has pleaded not guilty.

Comedic television series "Friends," which followed the lives of six New Yorkers navigating adulthood, dating and careers, drew a massive global following and made megastars of previously unknown actors.

Perry's role as the sarcastic man-child Chandler brought him fabulous wealth, but hid a dark struggle with addiction to painkillers and alcohol.

In 2018, he suffered a drug-related burst colon and underwent multiple surgeries.

In his 2022 memoir "Friends, Lovers and the Big Terrible Thing," Perry described going through detox dozens of times.

"I have mostly been sober since 2001," he wrote, "save for about sixty or seventy little mishaps."